Review of Pharmacological Guidelines for Schizophrenia a Systematic Review

Review

. 2017 Jan 6;vii(1):e013881.

doi: ten.1136/bmjopen-2016-013881.

Pharmacological guidelines for schizophrenia: a systematic review and comparison of recommendations for the first episode

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• PMID: 28062471
• PMCID: PMC5223704
• DOI: 10.1136/bmjopen-2016-013881

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Review

Pharmacological guidelines for schizophrenia: a systematic review and comparison of recommendations for the beginning episode

Dolores Keating  et al. BMJ Open. 2017 .

Complimentary PMC article

Abstruse

Objectives: Clinical practise guidelines (CPGs) back up the translation of research evidence into clinical practice. Key health questions in CPGs ensure that recommendations will be applicable to the clinical context in which the guideline is used. The objectives of this study were to identify CPGs for the pharmacological treatment of outset-episode schizophrenia; appraise the quality of these guidelines using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument; and compare recommendations in relation to the key health questions that are relevant to the pharmacological treatment of first-episode schizophrenia.

Methods: A multidisciplinary group identified primal health questions that are relevant to the pharmacological treatment of first-episode schizophrenia. The MEDLINE and EMBASE databases, websites of professional person organisations and international guideline repositories, were searched for CPGs that met the inclusion criteria. The AGREE Ii instrument was applied by iii raters and data were extracted from the guidelines in relation to the primal health questions.

Results: In total, 3299 records were screened. ten guidelines met the inclusion criteria. 3 guidelines scored well across all domains. Recommendations varied in specificity. Side consequence concerns, rather than comparative efficacy benefits, were a key consideration in antipsychotic choice. Antipsychotic medication is recommended for maintenance of remission post-obit a kickoff episode of schizophrenia just there is a paucity of evidence to guide elapsing of handling. Clozapine is universally regarded as the medication of pick for treatment resistance. There is less evidence to guide intendance for those who practice non respond to clozapine.

Conclusions: An private'due south feel of using antipsychotic medication for the initial treatment of first-episode schizophrenia may take implications for future engagement, adherence and outcome. While guidelines of good quality exist to assist in medicines optimisation, the evidence base required to answer key health questions relevant to the pharmacological handling of kickoff-episode schizophrenia is express.

Keywords: antipsychotic; psychosis.

Published past the BMJ Publishing Grouping Limited. For permission to use (where not already granted under a licence) please become to http://www.bmj.com/company/products-services/rights-and-licensing/.

Disharmonize of interest statement

Conflicts of Interest: None declared.

Figures

Figure 1

PRISMA diagram describing process of guideline selection.

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